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Contents:
  1. Description
  2. Cell death: protein misfolding and neurodegenerative diseases | SpringerLink
  3. Protein misfolding in neurodegenerative diseases: implications and strategies
  4. Marine Natural Products for Protein Misfolding Modulation

Westerheide and Richard I. Abstract The disruption of protein folding quality control results in the accumulation of a non-native protein species that can form oligomers, aggregates, and inclusions indicative of neurodegenerative disease.

Description

View this article with LENS. Prev Next Table of Contents. This Article First Published on August 1, doi: Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions.


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Responses Submit a Letter to the Editor. Google Scholar Articles by Westerheide, S. Articles by Morimoto, R. The studies involve expression, purification, and site-directed mutagenesis of these proteins using the tools of molecular biology, protein chemistry, structural biology, mammalian cell culture, toxicity studies, confocal microscopy and live cell imaging. In addition, Transmission Electron Microscopy and Dynamic Light Scattering is employed for visualizing structures and aggregate sizes.

Biomolecular interactions and stability studies are carried out using Isothermal Titration Calorimetry and Differential Scanning Calorimetry. Another protein of interest is transthyretin involved in peripheral neuropathy. We are also interested in understanding the role of water and weak interactions, and that of chemical chaperones and osmolytes on the stability, folding, misfolding and aggregation of a number of model proteins.

Insights gained from these studies are being applied for structurally and functionally stabilizing therapeutically important proteins like human insulin, industrially important enzymes and some cytokines. Membership of Learned Societies. Research activities. Cosolvent assisted protein refolding: Chymotrypsinogen as a model, G. Cosolvent assisted folding of proteins: Studies on citrate synthase and P22 tailspike protein, Rajesh Mishra Solvent mediated thermal stability and refolding of yeast hexokinase A, D.

Prasanna Kumar Studies on thermostabilization of protective antigen of B. Bhatnagar Effect of osmolytes of the polyol and amino acid series on the stability of glucose oxidase, Neeraj K. Mishra Jain Understanding the mechanism of the effect of polyols and polyphenols on the stability and amyloid fibril formation of recombinant human lysozyme, Fatima K. Zaidi Courses Taught. Reviewer of Ph. Reviewed Ph. Reviewer of Grants. Sponsored Projects. Ahluwalia-Achievements of a lifetime: From thermodynamics of model compounds to proteins, R.

Bhat and S. Deep, J. Administrative and other academic responsibilities.

Cell death: protein misfolding and neurodegenerative diseases | SpringerLink

Chairman, Committee to examine 5 year Admissions data and to look into the weightage for viva voce marks for admission in JNU, Member of Committee for looking into selection committee criteria and eligibility qualifications for direct recruitment of teachers in JNU, Biotechnology Paper setting for a number of years since Coordinator Ph. Biotechnology Paper setting for a number of years since Career: -. Lecturer, Deptt.

Postdoctoral Associate, Graduate Deptt. Kaushik Laboratory Techniques -2 credits M. Advances in Protein Chemistry-2 credits M. Sponsored Projects Effect of solvents on the thermal stability of proteins, Department of Science and Technology, Duration: Protein engineering of protective antigen from Bacillus anthracis : Computational and genetic engineering approach, Department of Biotechnology joint with Prof. Bhatnagar , Duration: Enhancing folding and stability of glucose oxidase by solvent engineering, Council of Scientific and Industrial Research, Duration: High precision microcalorimetric facility for monitoring biomolecular stability and interactions, DBT, Duration: From molecules to systems: Exploring biological space using chemical and synthetic biology, Department of Biotechnology, Govt.

Roy and R. Bhat, Biochim. Acta, Proteins Proteomics, doi. Jain, P. Singh, S. Roy, and R. Bhat , Biochemistry , 57 26 , — Resveratrol interferes with an early step in the fibrillation pathway of human lysozyme and modulates it towards less-toxic, off-pathway aggregates, F. Zaidi and R. Bhat, ChemBiochem , 19, Vashist, D. Prithvi Raj, U. Gupta, R. Bhat, J. Impact of structural stability of cold adapted Candida antarctica lipase B CaLB in relation to pH, chemical and thermal denaturation, G.

Khan, RSC Adv. Significantly enhanced heme retention ability of myoglobin engineered to mimic the third covalent linkage by non-axial histidine to heme vinyl in Synechocystis hemoglobin, S. Uppal, S, Salhotra, N. Mukhi, F. Zaidi, M. Seal, S. Ghosh Dey, R. Kundu, J. Biol Chem. Jain and R. Bhat, Neurobiology of Disease, 63, Polyol osmolytes stabilize native-like cooperative intermediate state of yeast hexokinase A at low pH, P.

Devaraneni, N. Mishra and R, Bhat, Biochimie, 94, Ahmad, G. Rabbani, N. Zaidi, S.

Singh, M. Rehan, M. Khan, S.

Rahman, Z. Quadri, M. Shadab, M. Ashraf, N. Subbarao, R. Bhat, and R. Khan, PLosOne 6 11 , e Dissecting the role of critical residues and substrate preference of a fatty acyl-coAsynthetase FadD13 of Mycobacterium tuberculosis , G. Khare, V. Bhat and A. Tyagi, PLoS One , 4 12 , e Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme, K. Akhatar, V. Gupta, A. Koul, N. Alam, R. Bamezai, J.

Directed evolution of an anti-human red blood cell antibody, A.

Gupta, V. Tripathi, A. Ali, R.

Protein misfolding in neurodegenerative diseases: implications and strategies

Bhat, and U. Pati, J. Chemical chaperone mediated protein folding: Stabilization of P22 tailspike folding intermediates by glycerol, R. Mishra, R. Seckler, Biol.

Marine Natural Products for Protein Misfolding Modulation

Stabilization of yeast hexokinase A by polyol osmolytes: Correlation with the physicochemical properties of aqueous solutions, A. Tiwari and R. Bhat, Biophys. Efficient refolding of aggregation prone citrate synthase by polyol osmolytes: How well are folding and stability aspects coupled? Seckler, and R. Bhat J. Ultra—rapid mixing experiments shed new light on the characteristics of the initial conformational ensemble during the folding of Ribonuclease A, E.